Urinary Metabolites of Epoxy Resin Hardeners and Mutagenicity of the Metabolites
نویسندگان
چکیده
منابع مشابه
Contact allergy to epoxy hardeners.
BACKGROUND Diglycidylether of bisphenol A resin is the most important sensitizer in epoxy systems, but a minority of patients develop concomitant or solitary contact allergy to epoxy hardeners. At the Finnish Institute of Occupational Health, several in-house test substances of epoxy hardeners have been tested in a special epoxy compound patch test series. OBJECTIVES To analyse the frequency ...
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Four urinary metabolites of the cytostatic drug cyclophosphamide were tested for mutagenicity in the Ames Salmonella assay: nornitrogen mustard (NM), 4-ketocyclophosphamide, 3-(2-chloroethyl)oxazolidone (OZ), and N,N'-bis(2-chloroethyl)piperazine. All four acted as direct base substitution mutagens although 4-ketocyclophosphamide showed an increase in mutagenicity after metabolic activation wit...
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Isoprene, a major commodity chemical used in production of polyisoprene elastomers, has been shown to be carcinogenic in rodents. Similar to findings for the structurally related compound butadiene, mice are more susceptible than rats to isoprene-induced toxicity and carcinogenicity. Although differences in uptake, and disposition of isoprene in rats and mice have been described, its in vivo bi...
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This laboratory has previously shown that, when animals are injected with microgram amounts of high specific activity C4-histamine, at least three radioactive metabolic products can be demonstrated in the urine. Paper chromatograms of the urine in butanol80, ethanol 10, and ammonia 30 showed three radioactive peaks. The following information regarding their identity has been published. Peak 1 i...
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Studies of gas chromatography/mass spectrometry (GC-MS) techniques carried out in 1994 on human clinical samples had already suggested a “potential for diagnosis and studies of metabolism in situ” . Researchers found that, when this technique is applied to blood or urine, it gives an insight into the infected host microbial metabolism . A more recent study (2002) on urinary organic metabolites,...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1983
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.25.7_647_2